The EPIBIOD project will study the regulation of gene expression in the hippocampus to combat Alzheimer’s disease

01 04 2014

 

DNA methylation is a biological mechanism that regulates gene expression. In other words, generally speaking, when a gene promoter is methylated that gene is not expressed. In light of the key role played by methylation in gene control, the scientific community has shown increasing interest in this biological process given its great potential in the fight against human disease.

Biomedical research into dementia is a priority worldwide due to the enormous medical, family and economic burden resulting from it. In 2010 it was calculated that dementia affected 35.6 million people worldwide, with an estimated economic cost of more than 600 billion dollars.

Continuing with this line of research, a cross-border network for biomedical research consortium known as Refbio has designed the EPIBIOD project in order to study whether DNA methylation in the hippocampus (the region of the brain in which Alzheimer’s disease starts) is altered in this disease.

The EPIBIOD project will broaden our understanding of the mechanisms involved in the onset of Alzheimer’s disease by studying this disease from a new perspective, namely regulation of gene expression. This may allow new molecules that can be used in diagnosis and treatment to be identified.

The project is coordinated and led by Navarrabiomed in collaboration with researchers from the Center for Biomedical Research of La Rioja and the Université Paul Sabatier in Toulouse. These researchers will jointly study the methylation of all human genes to find those which are differently regulated in the brain Alzheimer’s disease patients. They will also investigate the consequences of these changes on gene expression and neuronal development.

This project forms part of the cross-border biomedical research network Refbio, which involves biomedical research organisations from the regions of Navarre, Basque Country, La Rioja, Aragón and Midi Pyrénées.

 

Neuroepigenetics. The EPIBIOD project will study the regulation of gene expression in the hippocampus to combat Alzheimer’s disease.

The EPIBIOD project will study the regulation of gene expression in the hippocampus to combat Alzheimer’s disease.