HEart autonomic Afferences moDuLate braIN Epigenome

Growing evidence supports a strong link between cardiovascular disease (CD) and neurodegenerative disease.
To elucidate the mechanisms underlying this association we have developed a mouse model for cardiac deafferentation to study brain function.

Emerging evidence for epigenetic changes on RNA now exhibit the existence of another layer of epigenetic regulation where mRNA is subject to chemical changes affecting protein expression.
Recent works show a dynamic increase of m6A in the cortex links to experience dependant memory processes and alternations in m6A are concomitant with neurodegenerative disease such as Parkinson’s disease.

Here we aim to identify the molecular interface underlying this cardiac afferent relay to the brain that results in cognitive impairment.
Altogether we anticipate decoding the neuronal mRNA methylation profile as commanded by cardiac afferences to reveal the molecular signatures that permit CD precipitated neurodegenerative disorders.

Project Partners

Project manager : Anne PAVY-LETRAON
Centre Hospitalier Universitaire de Toulouse

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